Sep 27, 2023 · Our study suggests that the PI3K-AKT signaling axis is a critical element that resculpts the integrin signaling in favor of pro-inflammatory astrogliosis because AKT …

This review will discuss the contribution of PI3Ks in platelet integrin signaling, focusing on the role of specific members of class I PI3Ks and their downstream effector Akt on both integrin inside …

Feb 2, 2021 · In this study, we unveil a new intracellular mechanotransduction pathway in mechanically sensitive osteocytes via which integrin αVβ3 at dendritic processes senses shear …

Sep 1, 2015 · Phosphatidylinositol 3-Kinases (PI3Ks) have emerged as crucial players in platelet activation, and they are directly implicated in the regulation of integrin function.

Integrin αIIbβ3 mediated bidirectional signaling plays a critical role in thrombosis and haemostasis. Signaling mediated by the β3 subunit has been extensively studied, but αIIb …

Here we show that PI3K-dependent phosphorylation of Akt in response to ligation of β1-integrins occurs efficiently in the absence of FAK tyrosine phosphorylation. Akt S473 phosphorylation …

Jan 1, 2010 · Phosphoinositide (PI) 3-kinase (PI3K) signaling processes play an important role in regulating the adhesive function of integrin α IIb β 3, necessary for platelet spreading and …

Sep 27, 2023 · These findings reveal an unexpected function for PI3K-AKT in tauopathy-associated reactive astrogliosis, which may be a promising target for anti-inflammation-based …

Jan 1, 2013 · The present work suggests a dramatic regulatory input of PI3K into the regulation of β2 integrin activity, and processes dependent on this, by signalling through its effector ARAP3.

Myeloid cell PI3Kγ plays a key role in regulating tumor immune suppression by promoting integrin α4-dependent MDSC recruitment to tumors and by stimulating immune suppressive …