Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules.

Mar 1, 2024 · Platelet factor 4 (PF4) combines with heparin to form an antigen that could produce IgG antibodies and participate in heparin-induced thrombocytopenia (HIT). PF4 has attracted wide attention due to its role in novel coronavirus vaccine-19 (COVID-9)-induced immune thrombotic thrombocytopenia (VITT) and cognitive impairments.

Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated platelets, may cause a number of pathophysiological conditions. The most commonly known is heparin-induced thrombocytopenia (HIT), which develops in a ...

Aug 15, 2007 · PF4, a member of the CXC family of chemokines, is the most abundant protein in platelet α-granules and is released into the local environment following platelet activation. Although characterized by its heparin-binding activity more than 50 years ago, 1 PF4's physiologic activities remain in question.

PF4 Enhanced and PF4 IgG have been designed to detect antibodies implicated in causing Heparin Induced Thrombocytopenia (HIT). LIFECODES PF4 is offered in multiple kit formats allowing the flexibility to detect either IgG/A/M or IgG specific antibodies.

Herein, we discussed the characteristics and biological functions of PF4, summarized PF4-mediated signaling pathways, and discussed its multiple roles in diseases to inform novel approaches for successful clinical translational research.

Platelet factor 4 (PF4), also known as chemokine CXCL4, is a cationic, 7.8 kDa protein which forms tetramers at physiological pH and ionic strength [24-26]. PF4 is released from the alpha-granules of activated platelets as a complex with a chondroitin sulfate proteoglyan carrier [27,28].

Mar 30, 2025 · PF4 (Platelet Factor 4) is a Protein Coding gene. Diseases associated with PF4 include Erythromelalgia and Essential Thrombocythemia. Among its related pathways are MIF Mediated Glucocorticoid Regulation and Response to elevated platelet cytosolic Ca2+.

Feb 8, 2025 · Platelet factor 4-positive thrombi adhering to the ventricles of a ventricular assist device in patients with heparin-induced thrombocytopenia type II. Beiras-Fernandez A, et al. Transplant Proc, 2013 Jun. PMID 23769097. Synovial angiostatic non-ELR CXC chemokines in inflammatory arthritides: does CXCL4 designate chronicity of synovitis?

Explore the role of Gene Pf4 (Platelet Factor 4) in thrombosis, inflammation, and cancer research. Learn about its function, clinical significance, and potential therapeutic applications.