Among confirm+ patients, we found that higher anti-heparin/PF4 antibody OD values were present in patients who clearly met clinical criteria for HIT (HIT+; median OD 1.04) versus …

Antibodies against platelet factor 4 (PF4), a protein released from alpha-granules of activated platelets, may cause a number of pathophysiological conditions. The most commonly known is …

The probability of HIT antibodies (strong-positive SRA result) inferred by a positive PF4-dependent EIA varies considerably in relation to the magnitude of the EIA result, expressed as …

What is the OD result given in the anti-PF4 report and what is its significance? OD is the optical density; it is an indication of antibody strength. Antibody present in the patient sample binds to …

Thrombosis-free survival for patients who underwent heparin/PF4 ELISA for detecting the presence of the heparin/PF4 antibody based on the optical density (OD) cut-off of 0.4 (A) and …

The aim was firstly to evaluate the clinical utility of the PF4 ELISA confirmatory assay, secondly to examine the relationship between ELISA optical density (OD) value and clinical diagnosis of …

Nov 19, 2015 · There is mounting evidence supporting a positive correlation between definitive heparin-induced thrombocytopenia and optical density (OD) positivity from the widely available …

Oct 9, 2014 · Understanding why the endogenous protein PF4 becomes immunogenic when complexing with heparin is important for the development of other negatively charged drugs …

Results are reported as: 1) Heparin-induced thrombocytopenia (HIT) ELISA Optical Density (OD); 2) Heparin inhibition (%); 3) Interpretation. Typical patterns of results and interpretations are …

Objectives: To determine whether the magnitude of a positive EIA result, expressed in optical density (OD)units, predicts risk of HIT antibodies, defined as a strong-positive platelet …