Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4) . This chemokine is released from alpha-granules of activated platelets during platelet aggregation, and promotes blood coagulation by moderating the effects of heparin -like molecules.

Sep 1, 2002 · We provide evidence that platelet factor 4 (PF4), but not the related chemokine neutrophil-activating polypeptide-2, induced highly purified human natural killer (NK) cells to produce interleukin (IL)-8 in a time- and dosage-dependent manner. This ability was retained even while PF4 was bound to heparin.

Jan 11, 2007 · PF-4/CXCL4 is a member of the CXC chemokine family, which is mainly produced by platelets and known for its pleiotropic biological functions. Recently, the proteic product of a nonallelic variant gene of CXCL4 was isolated from human platelets and named as CXCL4L1.

PF4 expression is positively associated with expression of collagen in fibroblasts. Meanwhile, as a chemokine, it also stimulates collagen expression via interaction with CXCR3.

Dec 15, 2023 · We used CHX inhibition to block protein synthesis and measured specific protein amount with or without CHX by flow cytometry (PGK-1, Ly6e, CD88/C5ar1) and immunoblotting (PGK-1) and the corresponding mRNA abundance by qRT-PCR to estimate translation efficiency.

In this study, we show that PF4, but not ␤ -TG/NAP-2, induces highly purified, human NK cells to synthesize bioactive IL-8. This effect is regulated at the transcriptional level, and it is not...

Aug 15, 2007 · PF4, a member of the CXC family of chemokines, is the most abundant protein in platelet α-granules and is released into the local environment following platelet activation. Although characterized by its heparin-binding activity more than 50 years ago, 1 PF4's physiologic activities remain in question.

Mar 1, 2024 · Platelet factor 4 (PF4), also known as chemokine (C-X-C motif) ligand 4 (CXCL4), was the first chemokine identified with multiple biological functions. It was first discovered that PF4 could combine with the anticoagulant heparin to form an antigen that could produce IgG antibodies and participate in heparin-induced thrombocytopenia (HIT) [1, 2].

Sep 1, 2002 · We provide evidence that platelet factor 4 (PF4), but not the related chemokine neutrophil-activating polypeptide-2, induced highly purified human natural killer (NK) cells to produce interleukin (IL)-8 in a time- and dosage-dependent manner. This ability was retained even while PF4 was bound to heparin.

Mar 30, 2025 · PF4 (Platelet Factor 4) is a Protein Coding gene. Diseases associated with PF4 include Erythromelalgia and Essential Thrombocythemia. Among its related pathways are MIF Mediated Glucocorticoid Regulation and Response to elevated platelet cytosolic Ca2+.