Peptide transporter 1 (PepT 1) also known as solute carrier family 15 member 1 (SLC15A1) is a protein that in humans is encoded by SLC15A1 gene. [5] [6] PepT 1 is a solute carrier for …

Nov 3, 2021 · Besides the uptake of short peptides, peptide transporter 1 (PepT1) is a highly abundant drug transporter in the intestine and represents a major route for oral drug delivery. …

Mar 25, 2018 · The peptide transporter 1 (PepT1, SLC15A1) is abundantly expressed particularly in the intestinal tract and provides highly effective transport of amino acids in the form of di- …

PEPT1 (most recently reviewed in [1] and [5]) is a high capacity, low affinity, sodium-independent symporter, or cotransporter, which catalyzes the electrogenic uphill transport of L-enantiomers …

The Peptide Transporter 1 (PepT1) plays an important role in animal protein nutrition. This is a low-affinity/high-capacity, stereoselective transmembrane transporter that mediates the uptake …

PepT1 and PepT2 mediate the uptake of di or tripeptide substrates into intestinal and renal epithelial cells, respectively. Other sites of functional expression of the two proteins have also …

PEPT1 regulation by modification of the transmembrane proton flux and the intracellular pH. The function of PEPT1 is strictly dependent on the transmembrane proton gradient in combination …

Because PepT1 is expressed in the small intestine and is induced in the colon during inflammation, PepT1 is a potential target for treatment of both IBD and other diseases of the …

Dec 1, 2013 · PepT1 ablation resulted in a 23-fold reduction in peak plasma concentration and a 14-fold reduction in systemic exposure of cefadroxil after oral dosing [12 ••]. The authors …

PEPT1 is a vital member of the proton-dependent oligopeptide transporters family (POTs). Many studies have confirmed that PEPT1 plays a critical role in the absorption of dipeptides, …