Pyruvate dehydrogenase lipoamide kinase isozyme 4, mitochondrial (PDK4) is an enzyme that in humans is encoded by the PDK4 gene. [5][6] It codes for an isozyme of pyruvate …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

We explored if upregulated mRNA expression of the mitochondrial enzyme pyruvate dehydrogenase kinase 4 (PDK4) may be used as a surrogate marker of increased …

Oct 30, 2023 · In this Article, we aimed to characterize the senescence-associated metabolism and uncovered that that pyruvate dehydrogenase kinase isoform 4 (PDK4), a pyruvate …

Mar 30, 2025 · PDK4 (Pyruvate Dehydrogenase Kinase 4) is a Protein Coding gene. Diseases associated with PDK4 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …

PDK4 is a key regulator of PDC activity, pyruvate oxidation and glucose homeostasis [1,2]. The importance of PDK4 in metabolic regulation has been confirmed in PDK4 knock-out mice …

Identification of PDK4 as Hub Gene for Diabetic Nephropathy Using Co-Expression Network Analysis. High glucose promotes benign prostatic hyperplasia by downregulating PDK4 …

Nov 25, 2023 · Pyruvate dehydrogenase kinase 4 (PDK4), a key enzyme regulating energy metabolism, has been implicated in modulating cellular senescence and fibroblast function. …

Title: PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression. Promotive role of eukaryotic translation initiation factor …

Through mass spectrometry imaging and phenotype assessment, we ascertained that specific knockout of PDK4 in cardiomyocytes (PDK4 fl/fl Myh6 Cre, male, 6 weeks) led to a reduction …