Pyruvate dehydrogenase kinase isoform 2 (PDK2) also known as pyruvate dehydrogenase lipoamide kinase isozyme 2, mitochondrial is an enzyme that in humans is encoded by the PDK2 gene. [5][6] PDK2 is an isozyme of pyruvate dehydrogenase kinase.

PDK2 is a key regulator of glycolysis and oxidative phosphorylation, and its expression is increased in a variety of tumors. The metabolism of glutamine and glucose is recognized as a promising therapeutic target for the treatment of cancer.

Mar 30, 2025 · PDK2 (Pyruvate Dehydrogenase Kinase 2) is a Protein Coding gene. Diseases associated with PDK2 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and Mitochondrial Disease. Among its related pathways are Regulation of pyruvate metabolism and ESR-mediated signaling.

Pyruvate dehydrogenase kinase (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme which acts to inactivate the enzyme pyruvate dehydrogenase by phosphorylating it using ATP.

we identified PDK2 as the most up-regulated kinase encoding gene in Cisplatin resistant lung adenocarcinoma and PDK2-dependent Cisplatin-resistance promotes tumour growth of lung adenocarcinoma mainly through transcriptional regulation of CNNM3; MiR-422a regulates cellular metabolism and malignancy by targeting PDK2 in gastric cancer.

PDK 1-4 which are serine-specific kinases ranging from 45 to 48 kDa are the main players that phosphorylate and inactivate pyruvate dehydrogenase (PDH) E1α. PDK2 exhibits the highest phosphorylation activity on Ser293 of PDH E1α, followed by PDK4, PDK1, and then PDK3 .

Nov 20, 2020 · Here, we show that pyruvate dehydrogenase kinase (PDK)-2 plays a role in hypothalamic inflammation and its sequelae in mouse models of diabetes. Cell type-specific genetic ablation and...

In this review, we discuss several factors involved in the expressional regulation of PDK2 and PDK4, and introduce current studies aimed at providing a better understanding of the molecular mechanisms that underlie the development of metabolic diseases such as diabetes.

Mar 22, 2021 · Although underappreciated, this makes PDK2 particularly important for the minute-to-minute fine control of the pyruvate dehydrogenase complex and a major contributor to metabolic flexibility. The purpose of this review is to characterize the underappreciated role of PDK2 in liver metabolism.

Feb 8, 2025 · The findings suggest PDK2 is a potential therapeutic target for nonalcoholic fatty liver disease. PDK2/4 induction and the subsequent lactate surge induce the metabolic shift in the diabetic dorsal root ganglion thereby contributing to the …