PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways activated by several growth factors and hormones including insulin signaling.

Mar 30, 2025 · Complete information for PDK1 gene (Protein Coding), Pyruvate Dehydrogenase Kinase 1, including: function, proteins, disorders, pathways, orthologs, and expression.

PDK1 functions as a master kinase, phosphorylating and activating PKB/Akt, S6K and RSK. To learn more about the roles of PDK1, we generated mice that either lack PDK1 or possess PDK1 hypomorphic alleles, expressing only ∼10% of the normal level of PDK1.

We propose a model of lipid-dependent PDK1 activation in which PH domain-mediated autoinhibition is relieved by PIP 3 or PI (3,4)P 2 binding, leading to strongly cooperative kinase domain dimerization and switch-like trans -autophosphorylation at the membrane.

Aug 8, 2002 · 3-phosphoinositide dependent protein kinase-1 (PDK1) plays a key role in regulating signalling pathways by activating AGC kinases such as PKB/Akt and S6K. Here we describe the 2.0 Å crystal structure of the PDK1 kinase domain in complex with ATP.

Since the PH domain of PDK-1 interacts with phosphatidylinositol 3,4-bisphosphate PtdIns (3,4)P2, PtdIns (4,5)P2 and phosphor-nositides PtdIns (3,4,5)P3 with high affinity, PDK-1 is anchored at the plasma membrane. This close association shows a potential PI3K-dependent PDK1 membrane translocation.

PDK1 belongs to the family of pyruvate dehydrogenase (PDH) kinases (EC 2.7.11.2), which reversibly inactivate the mitochondrial PDH complex by ATP-dependent serine phosphorylation of the alpha subunit of the complex's E1 component (see 300502) (summary by …

3-Phosphoinositide-dependent kinase 1 (PDK1) phosphorylates the activation loop of a number of protein serine/threonine kinases of the AGC kinase superfamily, including protein kinase B (PKB; also called Akt), serum and glucocorticoid-induced kinase, protein kinase C isoforms, and the p70 ribosomal S6 kinase.

PDK1, encoded by the PDK1 gene, is an isozyme of pyruvate dehydrogenase kinase (PDK). It is a mitochondrial enzyme involved in the regulation of carbohydrate fuel homeostasis in mammals.

A protein kinase, termed PDK1, has been identified that phosphorylates PKB at Thr308 only in the presence of lipid vesicles containing phosphatidylinositol 3,4,5-trisphosphate [Ptdlns (3,4,5)P3] or phosphatidylinositol 3,4-bisphosphate [Ptdlns (3,4)P2]. Human …