Sep 1, 1999 · 3-phosphoinositide-dependent protein kinase-1 (PDK1) expressed in unstimulated 293 cells was phosphorylated at Ser-25, Ser-241, Ser-393, Ser-396 and Ser-410 and the level of phosphorylation of each site was unaffected by stimulation with insulin-like growth factor-1.

Apr 8, 2025 · Polyclonal Antibody for studying PDK1 (Ser241) phosphate. Validated for IP, WB. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-PDK1 (Ser241) Antibody (CST #3061) is ready to ship.

Apr 6, 2022 · In this study, we have elucidated the mechanism of phosphoinositide-driven PDK1 auto-activation. We show that PDK1 trans-autophosphorylation is mediated by a PIP3-mediated face-to-face...

Feb 1, 2018 · This review analyzes the up-to-date knowledge supporting PDK1 involvement in altered signaling in cancer, what cancer types and subtypes would benefit from a PDK1 targeting and the molecular mechanisms by which PDK1 is involved in tumors.

Phospho-PDK1 (Ser241) Antibody is a rabbit antibody raised against a short peptide from N human PDK1 sequence surrounding and containing phospho-Ser241. This antibody detects endogenous phosphorylated PDK1 (Ser241) proteins …

Antigen: Peptide sequence that includes phosphorylation site of serine 241 (A-N-S(p)-F-V) derived from human PDK1 and conjugated to KLH. Accession no.: O15530, NP_002604.1. Host Species: Rabbit . Specificity: This antibody detects human, mouse, and rat endogenous PDK1 only when phosphorylated at serine 241. APPLICATIONS

IMMUNOGEN: PDK1 (Phospho-Ser241) antibody was raised against a peptide sequence around phosphorylation site of serine 241 (A-N-S (p) -F-V) derived from Human PDK1. SPECIFICITY: This antibody detects endogenous level of PDK1 only when phosphorylated at serine 241.

KLH conjugated synthetic phosphopeptide derived from human PDK1 around the phosphorylation site of Ser241.

Sep 9, 1999 · 3-phosphoinositide-dependent protein kinase-1 (PDK1) expressed in unstimulated 293 cells was phosphorylated at Ser-25, Ser-241, Ser-393, Ser-396 and Ser-410 and the level of phosphorylation of each site was unaffected by stimulation with insulin-like growth factor-1.

Dec 1, 2015 · PDK1 is a transducer of PI3K signaling and activates multiple downstream effectors, thereby representing an essential hub coordinating signals coming from extracellular cues to the cytoskeletal machinery, the final executor of cell movement.