PDPK1 is a master kinase, which is crucial for the activation of AKT /PKB and many other AGC kinases including PKC, S6K, SGK. An important role for PDPK1 is in the signaling pathways …

Mar 30, 2025 · PDK1 (Pyruvate Dehydrogenase Kinase 1) is a Protein Coding gene. Diseases associated with PDK1 include Pyruvate Dehydrogenase E3-Binding Protein Deficiency and …

Pyruvate dehydrogenase kinase (PDK) can regulate the catalytic activity of pyruvate decarboxylation oxidation via the mitochondrial pyruvate dehydrogenase complex, and it …

PDK1 regulates the progression of esophageal squamous cell carcinoma through metabolic reprogramming. Circular RNA PDK1 targets miR-4731-5p to enhance TNXB expression in …

PDK1 is relevant in a variety of clinical conditions throughout the body. As PDK1 regulates the PDH complex, it has been proven to be an important regulator in certain cells, including the …

Apr 6, 2022 · PDK1 (3-phosphoinositide-dependent kinase 1) is a serine/threonine-protein kinase that plays a central role in regulating cell growth, survival, and proliferation. Knocking out …

PDK1 is a 63 KDa Ser/Thr kinase with carboxyl terminal PH domain that binds with high affinity to PIP3-containing regions of plasma membrane and phosphorylates the colocalised AKT at its …

Mar 1, 2022 · Acute myeloid leukemia remains difficult to treat due to strong genetic heterogeneity between and within individual patients. Here, we show that Pyruvate dehydrogenase kinase 1 …

Jan 4, 2025 · Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk.

Nov 7, 2023 · PDKs (PDK1–4) are important regulator enzymes of mitochondrial aerobic metabolism, which can inhibit the activity of the pyruvate dehydrogenase (PDH) complex by …