May 18, 2024 · The administration of PDE5 inhibitors (PDE5Is) hindered fibroblast activation through suppressing autophagy by inhibiting the ERK signaling pathway. Our findings suggest that autophagy plays a pivotal role in promoting BPH progression through fibroblast activation, while PDE5Is effectively suppress autophagy and fibroblast activation via the ...

Splice variants of PDE5, PDE10, and PDE11 families are also shown in boxes. The 3 iso-forms in the PDE4 family are illustrated and boxed. PDE3 enzymes produced by alternative translation initiation are boxed. Reported phos-phorylation sites are indicated with arrows. ERK phosphorylation site in PDE4A variants is absent.

May 18, 2024 · Our findings suggest that autophagy plays a pivotal role in promoting BPH progression through fibroblast activation, while PDE5Is effectively suppress autophagy and fibroblast activation via the ERK signaling pathway.

Jan 12, 2014 · Phosphodiesterase 5 (PDE5) specifically degrades cGMP and is highly abundant in the mammalian brain. Inhibition of cGMP hydrolysis by blocking PDE5 is a possible strategy to enhance the first step of neurogenesis, proliferation of neural stem cells (NSC).

The phosphodiesterases type 5 (PDE5) are catalytic enzymes converting the second messenger cyclic guanosine monophosphate (cGMP) to 5’ GMP. While intracellular cGMP reduction is associated with several detrimental effects, cGMP stabilization ...

Phosphodiesterase type 5 inhibitors (PDE5i) have long been used as an effective therapeutic option for the treatment of erectile dysfunction (ED). Different studies have demonstrated that PDE5i, by sensitizing insulin target tissues to insulin, play an important role in controlling the action of insulin and glucose metabolism, highlighting the ...

PDE5 inhibitors (PDE5-Is) are groundbreaking medications for treating ED. They increase cGMP levels, causing muscle relaxation and vasodilation in the penis, leading to erections. Their therapeutic potential extends beyond ED, with clinical approval for treating PAH, BPH, and LUTS.

High expression of PDE5 was found in early progressive BPH stromal cells. The administration of PDE5 inhibitors (PDE5Is) hindered fibroblast activation through suppressing autophagy by inhibiting the ERK signaling pathway.

High expression of PDE5 was found in early progressive BPH stromal cells. The administration of PDE5 inhibitors (PDE5Is) hindered fibroblast activation through suppressing autophagy by inhibiting the ERK signaling pathway.

Oct 10, 2008 · Using RNA interference and pharmacological inhibitors of PKG and ERK, we have shown that sildenafil-induced cardioprotection was associated with PKG-dependent phosphorylation of ERK, GSK3β, and increased expression of Bcl-2 in cardiomyocytes.