Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties …
Jan 15, 2019 · Here we identified a subset of tumor-reactive TILs bearing hallmarks of exhausted cells and central memory cells, including expression of the checkpoint protein PD-1 and the …
Lymphoid tissue residency: A key to understand Tcf-1+PD-1+ T cells
Deeper understanding of the biology of Tcf-1 + PD-1 + CD8 + T cells will lead to rational design of future immunotherapies. Here, we summarize recent findings about the migratory and resident …
TCF-1+ PD-1+ CD8+T cells are associated with the response to PD-1 …
Purpose: To determine whether TCF-1 + PD-1 + CD8 + T cells are associated with the response to PD-1 blockade in non-small cell lung cancer (NSCLC) patients. Methods: We investigated …
PD-1 blockade increases the self-renewal of stem-like CD8 T
Aug 25, 2023 · PD-1 + TCF-1 + stem-like CD8 T cells act as critical resource cells for maintaining T cell immunity in chronic viral infections and cancer. In addition, they provide the proliferative …
Characteristics and anatomic location of PD-1 - PNAS
Recent studies in chronic viral infections and cancers have defined a population of PD-1 + TCF1 + stem-like CD8 T cells. These self-renewing stem-like cells act as resource cells for maintaining …
A comprehensive profile of TCF1+ progenitor and TCF1− ... - Nature
Feb 14, 2022 · The programmed death-1 (PD-1)-blocking antibody nivolumab was the first immune checkpoint inhibitor approved by the United States Food and Drug Administration …
Epigenetic signature of PD-1+ TCF1+ CD8 T cells that act as …
PD-1+ TCF1+ stem-like CD8 T cells are critical for maintaining the T cell response during chronic viral infection and cancer, and provide the proliferative burst seen after PD-1 immunotherapy.
TCF-1+ PD-1+ CD8+T cells are associated with the response to PD-1 …
Nov 2, 2021 · To determine whether TCF-1 + PD-1 + CD8 + T cells are associated with the response to PD-1 blockade in non-small cell lung cancer (NSCLC) patients. We investigated …
Combination radiation and αPD-L1 enhance tumor control by
5 days ago · This subset is able to traffic to the tumor and differentiate into TIM-3+ TCF-1- cells. Finally, we found that ablation of the PD-1+ TCF-1+ T cell population attenuates the enhanced …
Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties …
Siddiqui et al. identify intratumoral, tumor-reactive Tcf1+PD-1+CD8+ T cells that display stem-like properties and that promote tumor control in response to vaccination and checkpoint blockade …