Feb 7, 2002 · Poly (ADP-ribosylation) of different nuclear acceptors by PARP-1 is an early event when a single strand DNA lesion is produced. We present here evidences that interplay …

Jul 20, 2020 · Additionally, PARP1 appeared to be required for the ATM-dependent activation of PLK3, which in turn activates p53, leading to its transcriptional damage response. Our results …

Montero et al. thus show that p53 not only induces apoptosis and senescence but also has a key role in the regulation of necrosis upon exposure to ROS, and they show that this effect is …

Feb 18, 2002 · In the present study we show that the role of PARP-1 in the p53-mediated response to DNA damage is dependent on the type of DNA lesion and on the upstream …

PARP-1 stabilizes p53 and retains the mutant p53, which is tumorigenic due to the loss of nuclear localization . The nuclear export of p53 is blocked by PARP-1-mediated PARylation that …

Jan 17, 2017 · Inhibition of poly (ADP-ribosyl)ation increased the levels of p53 protein, but not p53 mRNA, and enhanced the phosphorylation of p53 at Ser18. Experiments with specific …

PARP1 and p53 are key players in maintaining genomic stability, but their interplay is still not fully understood. We investigated the impact of PARP1 knockout on the DNA damage response …

Jun 23, 2023 · PARP-1 has been found positively or negatively regulate the expression of specific genes through its modulation of key transcription factors and other molecules, including NF …

Oct 5, 2017 · PARP-1 and p53 mRNA levels were determined by quantitative PCR (qPCR). Lymphocytes from MCI patients showed increased susceptibility to death, attaining …

Oct 5, 2017 · PARP-1 and p53 mRNA levels were determined by quantitative PCR (qPCR). Lymphocytes from MCI patients showed increased susceptibility to death, attaining …