PALB2 (partner and localizer of BRCA2) is a specific type of genetic mutation. Although PALB2 normally helps prevent cancer, when it mutates, it no longer works correctly, which means …

Learn how the PALB2 gene functions and how hereditary PALB2 mutations impact breast cancer risk Most breast cancers are sporadic, meaning they occur without any known cause or risk factors. Several factors, however, can significantly increase a woman’s risk of developing the disease, including older age, a family history of breast cancer, and inherited genetic mutations.

PALB2 was recently identified as a susceptibility gene for familial pancreatic cancer by scientists at the Sol Goldman Pancreatic Cancer Research Center at Johns Hopkins. This has paved for the way for developing a new gene test for families where pancreatic cancer occurs in multiple family members. [18] .

Jul 17, 2023 · If you both have a mutation in the PALB2 gene, which is rare, there’s a chance your child could be born with a serious condition called Fanconi Anemia (FA). FA is a genetic …

People with an inherited PALB2 mutation have an increased risk for cancer. Read about medical options for lowering cancer risk or detecting it early. FORCE is here to guide you.

Feb 14, 2025 · Evidence-based, expert-reviewed summary about the PALB2 gene, the cancer risks associated with PALB2, screening, risk-reduction, treatment, and prognosis.

Nov 9, 2021 · PALB2 — sometimes referred to as BRCA3 — has been included since about 2012 in panels of multiple genes tested for inherited breast cancer susceptibility or more broadly for a wider range of cancer predisposition.

Mar 24, 2025 · Read about the latest expert guidelines for cancer screening and prevention for people with a PALB2 mutation. Learn about research studies enrolling high-risk patients.

Mar 30, 2025 · Complete information for PALB2 gene (Protein Coding), Partner And Localizer Of BRCA2, including: function, proteins, disorders, pathways, orthologs, and expression.

PALB2 functions as a tumor suppressor and participates in the maintenance of genome integrity. In this review, we summarize the current knowledge of the biological roles of the multifaceted PALB2 protein and of its regulation.