Ribosomal protein S6 kinase beta-1 (S6K1), also known as p70S6 kinase (p70S6K, p70-S6K), is an enzyme (specifically, a protein kinase) that in humans is encoded by the RPS6KB1 gene. [5][6] It is a serine/threonine kinase that acts downstream of PIP3 and phosphoinositide-dependent kinase-1 in the PI3 kinase pathway. [7] .

Recent studies have suggested that plasma p70S6K is a reliable index for the monitoring of patient response to mTOR inhibitors. Therefore, a better understanding of p70S6K and its role in various pathological conditions could enable the development of strategies to aid diagnosis, prognosis and treatment schedules.

Jun 1, 2022 · Different screening strategies are used to identify novel classes of p70 S6K inhibitors. p70 S6 kinase (p70 S6K) is best known for its regulatory roles in protein synthesis and cell growth by phosphorylating its primary substrate, ribosomal protein …

In this review, we will discuss current findings of p70 S6K in the control of actin cytoskeleton dynamics. In addition, the potential role of p70 S6K in spermatogenesis and testicular function will be highlighted. Keywords: actin, cancer, Cdc42, germ cell, p70 S6 kinase, Rac1, spermatogenesis, testis.

In response to mitogen stimulation, p70 S6 kinase activation up-regulates ribosomal biosynthesis and enhances the translational capacity of the cell. In Alzheimer’s disease (AD), there is a marked increase in total tau protein in the form of abnormally hyperphosphorylated tau (PHF-tau) in neurons with neurofibrillary tangles (NFTs).

Feb 12, 2022 · We demonstrate that p70 ribosomal S6 kinase activity peaks in oligodendrocyte lineage cells at the time when they transition to myelinating oligodendrocytes during developmental myelination in the mouse spinal cord.

In mammalian cells, p70S6 kinase is likely to be a good candidate for the control of the autophagic signaling pathway downstream of the mammalian TOR (mTOR). In rat hepatocytes, an amino-acid-dependent correlation between the phosphorylation of the ribosomal S6 protein, a p70S6 kinase substrate, and the inhibition of autophagy has been shown ...

We report the crystal structures of the kinase domain of p70S6K1 bound to staurosporine in both the unphosphorylated state and in the 3′-phosphoinositide-dependent kinase-1-phosphorylated state in which Thr-252 of the activation loop is phosphorylated.

Aug 7, 2001 · Here, we purified membrane-based 70-kDa ribosomal protein S6 kinase (p70S6K) as a BAD S136-specific kinase. Rapamycin, which blocks mitochondrial-based p70S6K activity, inhibits IGF-1-induced BAD S136 phosphorylation and cell survival. The p70S6K-deficient cells support the importance of IGF-1-induced BAD S136 phosphorylation by this kinase.

Jul 24, 2008 · Our results show for the first time the genome-wide transcriptional consequences of PI3K/mTOR pathway and RPS6KB1 inhibitions in breast cancer, suggesting novel downstream targets for PI3K/mTOR pathway and p70S6 kinase.