TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features...

The p53 pathway is a complex cellular stress response network with multiple diverse inputs and downstream outputs relevant to its role as a tumor suppressor pathway. While inroads have been made in understanding the biology and signaling in the p53 pathway, the p53 family, transcriptional readouts, and effects of an array of mutants, the ...

Effects of different p53 status-mediated signaling pathways on the tumor microenvironment References; Wild-type p53-mediated pathway Mut-type p53-mediated pathway p53 inactivation-mediated pathway p53 deletion-mediated pathway; Chronic inflammation-related mechanism:

Potential of p53 signaling targeting for cancer therapy. Because wild-type p53 is an efficient promoter of apoptosis and senescence in tumor cells, reactivating wild-type characteristics of p53 mutants, which are commonly overexpressed in cancer, is a viable therapeutic strategy.

Feb 10, 2025 · The p53 signaling pathway is essential for maintaining cellular integrity and preventing tumorigenesis by regulating cell cycle progression, DNA repair, apoptosis, and senescence. Known as the “guardian of the genome,” it responds to various stress signals, ensuring damaged cells do not proliferate uncontrollably.

Apr 18, 2005 · The p53 pathway responds to stresses that can disrupt the fidelity of DNA replication and cell division. A stress signal is transmitted to the p53 protein by post-translational modifications.

p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell …

Mar 19, 2025 · Approximately half of all cancers have p53 inactivating mutations, in addition to which most malignancies inactivate the p53 pathway by increasing p53 inhibitors, decreasing p53 activators, or inactivating p53 downstream targets. ... Signal Transduction Tumor Microenvironment* / genetics Tumor Microenvironment* / immunology ...

Aug 1, 2021 · TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles in development, aging and cell differentiation [2].