Studies have shown that cells with p53 mutations have significantly lower levels of PUMA, making it a good candidate for a protein marker of p53 mutations, providing a simpler method for testing for p53 mutations.

We have identified a novel gene named PUMA (p53 upregulated modulator of apoptosis) as a target for activation by p53. This gene encodes two BH3 domain-containing proteins (PUMA-alpha and PUMA-beta) that are induced in cells following p53 activation.

PUMA (p53 upregulated modulator of apoptosis) is a Bcl-2 homology 3 (BH3)-only Bcl-2 family member and a critical mediator of p53-dependent and -independent apoptosis induced by a wide variety of stimuli, including genotoxic stress, deregulated ...

Jun 30, 2021 · Our data indicate that the p53 null allele completely rescues the mdm2 null lethality, while the puma null completely rescues the mdm2 null apoptosis but only partially rescues the phenotype....

P53 up-regulated modulator of apoptosis (PUMA), a pro-apoptotic BCL-2 homology 3 (BH3)-only member of the BCL-2 family, is a direct transcriptional target of P53 that elicits mitochondrial apoptosis under treatment with radiation and chemotherapy. ...

Our results demonstrated that transcriptional activation of PUMA, which requires the direct binding of nuclear p53 to the p53-binding sites in the PUMA promoter, accounts for nearly all of DNA damage-induced PUMA activation and PUMA-mediated apoptosis.

Mar 1, 2001 · We have identified a novel gene named PUMA (p 53 u pregulated m odulator of a poptosis) as a target for activation by p53. This gene encodes two BH3 domain–containing proteins (PUMA-α and PUMA-β) that are induced in cells following p53 activation.

PUMA (p53 upregulated modulator of apoptosis) is a pro-apoptotic member of the BH3-only subgroup of the Bcl-2 family. It is a key mediator of p53-dependent and p53-independent apoptosis and was identified 10 years ago.

Sep 25, 2003 · Our results demonstrate that Puma is a critical mediator of p53-induced cell death and actually accounts for nearly all of the apoptotic activity attributed to p53 in primary hematopoietic cells and the CNS in response to γ-IR or oncogenes (c-Myc).

Nov 18, 2005 · SLUG exerts this protective role by repressing Puma, a proapoptotic target of p53. PUMA is also a key coordinator of apoptosis mediated by both nuclear and cytoplasmic functions of p53 (Chipuk et al., 2005).