The role of p53 in liver fibrosis - PMC - PubMed Central (PMC)
Here, we systematically discuss the regulation of p53 in different liver cells (hepatocytes, immune cells, HSCs, etc) and the role of p53 in the development of liver fibrosis, and propose possible interventions to prevent the pathogenic processes of liver fibrosis.
p53 as a Dichotomous Regulator of Liver Disease: The …
Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has emerged as an important regulator of liver homeostasis and …
p53-mediated redox control promotes liver regeneration and …
Oct 9, 2021 · Here, we show that p53 functions to support repair and recovery from CCl 4 -mediated liver damage, control reactive oxygen species (ROS) and limit the development of …
- Author: Timothy J Humpton, Holly Hall, Christos Kiourtis, Colin Nixon, William Clark, Ann Hedley, Robin Shaw...
- Publish Year: 2021
p53 as a Dichotomous Regulator of Liver Disease: The Dose
Mar 20, 2018 · Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has …
- Author: Jelena Krstic, Markus Galhuber, Tim J Schulz, Michael Schupp, Andreas Prokesch
- Publish Year: 2018
- bing.com › videosWatch full video
O -GlcNAcylated p53 in the liver modulates hepatic glucose
Aug 20, 2021 · More specifically, p53 binds to PCK1 promoter and regulates its transcriptional activation, thereby controlling hepatic glucose production. Mice lacking p53 in the liver show a …
- Author: Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Ch...
- Publish Year: 2021
The role of p53 in liver fibrosis - PubMed
Oct 24, 2022 · The tumor suppressor p53 is the central hub of a molecular network, which controls cell proliferation and death, and also plays an important role in the occurrence and …
- People also ask
p53 as a double-edged sword in the progression of non ... - PubMed
Dec 15, 2018 · Tumor-suppressor factor p53 has a crucial role in many signaling pathways that induce apoptosis and has become an emerging focus for liver disease research. Recent …
p53 in liver pathologies—taking the good with the bad
Nov 19, 2014 · In this review, we will demonstrate the diverse activities of p53 in the liver. Interestingly, some of these activities may protect the liver from cancer in the short term, yet in the long term, p53 may lead to malignant transformation.
p53 as a Dichotomous Regulator of Liver Disease: The Dose Makes …
Mar 20, 2018 · Given that liver is a dynamic tissue with direct exposition to ingested nutrients, hepatic p53, by integrating cellular stress response, metabolism and cell cycle regulation, has …
p53-mediated redox control promotes liver regeneration and …
Liver p53 engages Cyp2a5/CYP2A6 to support redox control during CCl 4-mediated liver regeneration. Given the differences in redox control between Albumin-Cre; p53 WT/WT and …
Related searches for P53 Liver
- Some results have been removed
