Aug 29, 1996 · The transcription factor interferon regulatory factor (IRF)-1 is essential for the regulation of the interferon system, inhibits cell growth, and manifests tumour-suppressor activities. Here we show that mouse embryonic fibroblasts (EFs) lacking IRF-1 are deficient in their ability to undergo DNA-damage-induced cell-cycle arrest.

Interferon regulatory factor 1 (IRF-1) and p53 control distinct sets of downstream genes; however, these two antioncogenic transcription factors converge to regulate p21 gene expression and to inhibit tumor formation.

Nov 6, 2002 · We demonstrate that IRF-1 and the tumour suppressor protein p53 are coordinately up-regulated during the response to DNA damage in an ATM-dependent manner.

Upon DNA damage, IRF1 protein levels normally increase as a result of increased mRNA expression and protein stability, so as to act on the CDKNA1 promoter region containing the IRF1- and p53-binding sites. 25,26 In the context of DNA repair, IRF1 positively regulates the expression of the DNA repair protein BRIP1, also known as Fanconi anemia ge...

IRF-1 coupled on the p21 promoter to increase CDK4’s cell cycle arrest ability and Cyclin E inhibition, as well as lessening DNA synthesis. Meanwhile, IRF-1 might also combine with p53 to have an anti-tumor effect due to p53-induced apoptosis signaling and …

Beyond its function as a transcription factor, IRF-1 has also been shown to trans-activate the tumour suppressor protein p53 through the recruitment of its co-factor p300. [8] IRF-1 has been shown to play roles in the immune response, regulating apoptosis, DNA …

Aug 29, 1996 · Here we show that mouse embryonic fibroblasts (EFs) lacking IRF-1 are deficient in their ability to undergo DNA-damage-induced cell-cycle arrest. A similar phenotype has been observed in EFs...

Jul 16, 2003 · Our study reveals a hitherto unrecognized link between p53 and IFN-α/β in tumour suppression and antiviral immunity, which may have therapeutic implications.

May 1, 2001 · In four tumors with reduced IRF-1 expression but normal p21 expression, p53 mutations were not detected. We believe that p21 expression was rescued by wild-type p53 in such cases. These results suggest that p53 predominantly and IRF-1 cooperatively regulate p21 expression in HCC.

Feb 1, 1998 · Here, we report the consequences of IRF-1 deficiency for apoptosis, cell cycle arrest, and DNA repair in primary hepatocytes after DNA damage and extend previous work on the role of p53 in hepatocytes.