p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers.

TP53 is a gene that encodes for the p53 tumor suppressor protein, commonly referred to as the “Guardian of the Genome” [1]. Its main biological function appears to involve the protection of the DNA integrity of the cell. TP53 plays additional roles …

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features of...

p53 is an important tumour-suppressor protein that is altered in most cancers. p53 activates various responses, including cell-cycle arrest and apoptosis. Each of these appears to contribute...

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a history that dates back to 1979 when p53 was discovered.

p53′s tumor-suppressive activity has been found to limit tumor cell proliferation not only within cells but also in the extracellular space. Thus, the loss of p53 has a profound impact on the secretome composition of cancer cells and marks the transition to invasiveness.

p53 inhibits the NF-κB pathway thereby suppressing the expression of cytokines and chemokines and reducing the accumulation of ROS. p53 mutant proteins can participate in the cGAS-STING-TBK1-IRF3 signaling pathway to inhibit tumor immunosurveillance, thereby eliminating IFN-I responses and innate immune activation.

Mar 28, 2024 · We describe here the paradox of how, depending on its mutational status in cancer, p53 can be both a tumor suppressor and an apparent oncogene. The major challenge of translating the vast store of p53 knowledge into clinical practice is discussed as well. We start by recounting the story of how p53 came to be so renowned. 2.

Mar 1, 2019 · Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence.

May 9, 2024 · p53 plays a central role in suppressing tumorigenesis. In this issue, Liu et al. review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that largely expand the …