Mar 1, 2007 · In mice, the manipulation of cell cycle inhibitors such as CDKN1B (p27) and CDKN1A (p21) modifies the risk of developing atherosclerosis. In humans, CDKN1A, CDKN1B and CDKN1C (p57) are differentially expressed in normal versus atherosclerotic vessels.

Transcription for p27 is activated by FoxO in response to cytokines, promyelocytic leukaemia proteins, and nuclear Akt signaling. [17] P27 transcription has also been linked to another tumor suppressor gene, MEN1, in pancreatic islet cells where it promotes CDKN1B expression. [17]

Jul 1, 2008 · Notably, loss of expression or function of two G1-checkpoint CDK inhibitors - p21 (CDKN1A) and p27 (CDKN1B) - has been implicated in the genesis or progression of many human malignancies. Additionally, there is a growing body of evidence suggesting that functional loss of p21 or p27 can mediate a drug-resistance phenotype.

Mar 30, 2025 · CDKN1A (Cyclin Dependent Kinase Inhibitor 1A) is a Protein Coding gene. Diseases associated with CDKN1A include Bladder Cancer and Hyperparathyroidism. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and Defective binding of RB1 mutants to E2F1, (E2F2, E2F3).

Jun 21, 2018 · Here, we show that only mitochondrial p27—but not nuclear p27—rescues the loss of migratory capacity induced by knockdown of endogenous p27, revealing a causal, direct link between mitochondrial localization of p27 and endothelial cell migration.

Aug 27, 2021 · Preeclampsia (PE), a gestational hypertensive disease originating from the placenta, is characterized by an imbalance of various cellular processes. The cell cycle regulator p21 Cip1/CDKN1A (p21) and its family members p27 and p57 regulate signaling pathways fundamental to placental development.

The CDKN1B gene provides instructions for making a protein called p27. This protein is found in cells and tissues throughout the body. Within cells, p27 is located primarily in the nucleus, …

Jan 1, 2018 · E47 uniformly inhibited PDA cell-cycle progression by decreasing expression of MYC, increasing the level of CDKN1B/p27 KIP1, and restoring RB tumor-suppressor function. The molecular mechanisms by which E47 elicited these changes included altering both RNA transcript levels and protein stability of MYC and CDKN1B/p27KIP1.

Cyclin-dependent kinase inhibitors p21 (Cip1) (CDKN1A) and p27 (Kip1) (CDKN1B) are expressed in Leydig cells. Previously, we reported that Cdkn1b knockout in the mouse led to increased Leydig cell proliferative capacity and lower steroidogenesis.

Dec 2, 2013 · HDACi transcriptionally activate CDKN1A, and it has been proposed that induction of p21 waf1/cip1 can determine if a cell undergoes apoptosis or cell cycle arrest following HDACi treatment.