Apr 23, 2024 · Both p53–p21 and p16 directly regulate the SASP: p21 supports an early secretory phenotype that includes CXCL14 and IGFBP3, which puts stressed or senescent cells under …

We found that p21—in addition to its function in maintaining the cell-cycle arrest of SNCs—has a prominent role in establishing the SASP through retinoblastoma protein (Rb)–dependent …

p21 regulates the SASP through Rb-dependent transcription. In our initial screen, we exposed primary mouse embryonic fibroblasts (MEFs) to three distinct senescence-inducing stressors: …

p21-dependent cellular senescence and SASP have been shown to positively impact wound healing. In the following sections, we will explore the role of p21 in various aspects of tissue …

The p21-induced secretome is characterized by the release of additional immunosurveillance factors, in particular Cxcl14, which are lacking in the p16INK4A-induced SASP. Consequently, …

Apr 24, 2024 · Cellular senescence is a state of terminal growth arrest associated with the upregulation of different cell cycle inhibitors, mainly p16 and p21, structural and metabolic …

Oct 7, 2021 · The p21-Cre mouse model allows us to suppress the SASP only in p21 high cells, so it is a cleaner system for examining the contribution of the SASP to age-related disorders.

Feb 15, 2018 · Here we demonstrated that various melanoma cell lines adopted senescence phenotype after CDDP treatment in contrast to the other types of tumour cells. CDDP …

Jan 1, 2023 · We show that p21 induces several core properties of cellular senescence in skeletal muscle, including an altered transcriptome, DNA damage, mitochondrial dysfunction, and the …

Jun 12, 2017 · Here, we show that the CDK inhibitor p21 (CDKN 1A) maintains the viability of DNA damage‐induced senescent cells. Upon p21 knockdown, senescent cells acquired …