Here, we report that the cell cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell fate. p21 activates retinoblastoma protein (Rb)-dependent transcription at select gene promoters to generate a complex bioactive secretome, termed p21-activated secretory phenotype (PASP).

Through this approach, we identified p21 (Cdkn1a), which encodes the cyclin-dependent kinase (CDK) inhibitor p21, and conducted an in-depth analysis of its functions from the time cells first experience stress until they have become senescent.

Trop-2 is a novel target for ADC therapy because of its high expression by many solid cancers. The rational development of IMMU-132 represents a paradigm shift as an ADC that binds a well-known moderately-cytotoxic drug, SN-38, to the anti-Trop-2 antibody.

Among those genes whose expression is highly upregulated during stress is the cyclin-dependent kinase inhibitor p21, which plays an important role in regulating cell growth (12,24,40). An important component of the stress response is a temporary or permanent alteration in …

In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have critical roles in p21 expression and activity.

Sep 1, 1996 · In the present study, the authors immunohisto- chemically stained p21 and p53 proteins in formalin- fixed, paraffin-embedded sections of human colorectal cancers to investigate the relationship between wall~ cipl/sdil and mutant p53 expression in human solid tumors.

Jul 3, 2019 · The cyclin-dependent kinase inhibitor p21 is usually considered to be a key promoter of the latter. Hsu and colleagues elegantly demonstrated in vitro that initial expression of p21 after chemotherapy exposure controls downstream cell fate after DNA damage induced by 1-day treatment with doxorubicin.

Sep 19, 2023 · Our data reveal the importance of p21 in controlling the cell cycle and preventing exhaustion of Th1 cells. Furthermore, we unveil the therapeutic potential of cyclin-dependent kinase inhibitors such as palbociclib to reduce T-cell exhaustion for future treatment of patients with colorectal cancer.

Oct 29, 2021 · Here, we report that the cell-cycle inhibitor p21 places cells under immunosurveillance to establish a biological timer mechanism that controls cell fate. p21 activates retinoblastoma protein (Rb)–dependent transcription at select gene promoters to generate a complex bioactive secretome, termed p21-activated secretory phenotype (PASP).

Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin–CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors.