Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference …

p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions …

Dec 11, 2024 · This International Conference on Harmonization (ICH) guidance provides a unified standard for the European Union, Japan, and the United States to facilitate the mutual …

Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin–CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries …

Oct 23, 2020 · Cell cycle cdk inhibitor p21CIP1 has a central and paradoxical role in the regulatory crossroads leading to senescence, apoptosis, or differentiation. p21 is an essential …

The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other …

The International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) is unique in bringing together the regulatory authorities and pharmaceutical …

由于p21是p53肿瘤抑制因子的转录靶点，由于基因毒性应激暴露，p21在含有稳定p53的细胞中表达增加。 在所有成人组织中都有表达，在大脑中表达水平降低5倍。 由p53/TP53、mezerin ( …

Cytoplasmic p21 conveys an anti-apoptotic function in many tumor cells through its induction by the DNA damage responsive p53 pathway, such that attenuation of p21 sensitizes cancer cells …

Nov 3, 2023 · In the present study, we examined the immuno-histochemical (IHC) expression of p21 as a novel marker of liver metastases in primary PET tissues and defined the most …