Apr 1, 2013 · IL-6, a phosphorylated glycoprotein of a molecular weight of 26 kDa, is a T cell-derived B cell stimulating factor. The cDNA encoding IL-6 was cloned and reported by Hirano et al. in 1986. The human gene for IL-6 is mapped to 7p15–p21 chromosome [1].

Jan 25, 2025 · This study investigates the role of interleukin-6 receptor (IL-6R) in mediating IL-6 signaling and its contribution to OA progression. Here, significantly elevated IL-6R expression is identified in degenerated cartilage of OA patients.

Feb 19, 2021 · IL-6 antibody inhibited the activation of STAT3 and the senescence of bone mesenchymal stem cells (BMSCs) from WT mice in vitro, while rescued IL-6 induced senescence of BMSCs from IL-6 KO mice through the STAT3/p53/p21 pathway.

Jan 23, 2025 · Our findings indicate that IL-6 drives the activation of the p53/p21 pathway by downregulating SIRT1, thereby inducing cellular senescence. Additionally, the IL-6/sIL-6R complex treatment leads to decreased SIRT1 levels, which increases the acetylation of SOX9.

Jan 15, 2003 · Analyses of p21-deficient mouse synovial fibroblasts reveal a 100-fold increase in IL-6 protein and enhance IL-6 and MMP-3 mRNA. Restoration of p21, but not overexpression of Rb, which also induces G (0)/G (1) cell cycle arrest, …

Apr 1, 2023 · We demonstrated that hesperidin could alleviate bleomycin-induced pulmonary fibrosis in mice. The expression level of senescence marker proteins p53, p21, and p16 was were downregulated, along with the myofibroblast marker α-SMA.

Dec 30, 2005 · Our findings suggest that IL-6 directly inhibits hepatocyte proliferation via a p21cip1-dependent mechanism and indirectly enhances hepatocyte proliferation via stimulating nonparenchymal cells to produce HGF. SOCS3 negatively regulates liver regeneration.

Feb 12, 2015 · Our present study revealed that upregulation of PAK1 kinase activity conferred stem-like phenotype via NF- κ B/IL-6 activation in vitro and in vivo that defines a novel …

Feb 3, 2014 · Administration of IL-6 in KO mice restored p21 and DNA repair enzyme expression to wild-type levels and survival was improved. IL-6 caused cell cycle arrest and delayed proliferation during the first day after PH.

Jul 1, 1997 · In the present report, we cultured MM cell lines and patient cells with IL-6 and/or dexamethasone (Dex) and characterized changes in cell cycle; expression and association of cyclins, CDKs, and CDIs; and phosphorylation of pRB.