Jan 25, 2024 · A. p16 immunohistochemistry is not recommended as a routine adjunct assessment when the biopsy interpretation is negative, CIN I or CIN III. Strong and diffuse block staining for p16 supports a categorization of precancerous disease. Any identified p16 positive area must meet H&E morphologic criteria for a high grade lesion to reinterpreted as ...

Human papillomavirus (HPV) testing p16 (by immunohistochemistry) for anogenital carcinomas and premalignant lesions Negative (cytoplasmic only staining, patchy nonblock type staining or diffuse blush / weak intensity staining)

Sep 3, 2020 · Endometrial serous carcinoma (ESC): Both can have papillary architecture Prominent pleomorphism and mitotic activity Arises in background of atrophy and often within endometrial polyps Apical borders are hobnailed and exfoliative, i.e. they appear to shed cells Positive for both p16 (diffuse, block-like) and p53 (aberrant patterns, see Negative ...

Mar 29, 2021 · p16: diffuse and strong nuclear and cytoplasmic reactivity (block type staining); improper use / interpretation may lead to overdiagnosis of HSIL Surgical excision is the treatment of choice, except during pregnancy or CIN II in females < 25 years old

Immunostains, routine stains and CD markers at PathologyOutlines.com

Mar 4, 2021 · Malignant neoplasm of mesothelial differentiation that arises from mesothelial lining cells of the pleura

Oct 18, 2022 · A 53 year old woman presents to the gynecologist with chief complaint of vaginal bleeding. An endometrial biopsy is performed and shows fragments of ciliated inactive endometrial tissue with foci of cytologic atypia. Immunohistochemical studies show a wild type pattern of p53 expression, patchy expression of p16 and low Ki67 proliferative index.

Sep 22, 2022 · Condyloma acuminatum is a benign papillomatous squamous proliferation with a fibrovascular core, caused by human papillomavirus (HPV) infection

Dec 15, 2020 · Nasal cavity, paranasal sinuses, nasopharynx - Nasopharyngeal carcinoma - general

Jun 22, 2021 · Malignant melanocytic tumor arising from melanocytes in the skin, mucosa and autochthonous melanocytes from numerous internal organs (i.e. GI tract, CNS, etc.)