Carbapenem resistance due to OXA-type carbapenemases seriously limits therapeutic options in nosocomial infections caused by Acinetobacter baumannii. Previous studies have shown the …

From the 1980s onwards, isolates of Acinetobacter baumannii that were resistant to the carbapenems emerged, manifested by plasmid-encoded β-lactamases (OXA-23, OXA-40, and …

Carbapenem resistance among A. baumannii was primarily associated with production of acquired CHDLs including OXA-23 and OXA-40. Keywords: Acinetobacter baumannii; CHDL; …

OXA enzymes of Acinetobacter are divided into five phylogenetic groups: acquired enzymes OXA-23-like, OXA-24/40-like, OXA-58-like OXA-143-like, and OXA-235-like [5,13]. The enzymes of …

The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene …

May 1, 2020 · In this study we found that the mechanism of their resistance is carbapenemase production by bla OXA genes including bla OXA-23, bla OXA-40, bla OXA-58, and bla OXA-51 …

May 16, 2022 · The high rate of carbapenem resistance in Enterobacteriaceae has become a global therapeutic concern. Objectives: The study investigated OXA-23, OXA-24, OXA-40, …

Sequencing identified this enzyme, OXA-40, as a variant of the OXA-24-OXA-25-OXA-26 cluster. Eighty-two carbapenem-resistant isolates of Acinetobacter baumannii from a single hospital in …

Oct 26, 2016 · OXA-24/40 was originally active against penicillin and carbapenem classes of β-lactams, but a clinical variant of OXA-24/40, the single-site substitution mutant P227S, has …

OXA-23-like β-lactamase enzymes have been found in outbreak isolates collected in the UK, East Asia, and South America, while OXA-40/24-like β-lactamases were found in the United States …