In the present study, we demonstrate a novel role of Olig2 in the terminal differentiation of sensory neurons by analyzing the cell identity of Olig2-positive cells in the OE and the phenotypes of …

Jan 1, 2022 · Oligodendrocyte transcription factor 2 (Olig2) is a basic helix-loop-helix transcription factor, involved in the dorsoventral patterning of embryonic spinal cords, and is indispensable …

Mar 17, 2022 · Here, we uncover a non-canonical function of OLIG2 in transcriptional repression to modulate myelinogenesis by functionally interacting with tri-methyltransferase SETDB1.

Nov 9, 2022 · Instead, we find that Olig2 is required for immature OL maturation, myelination, and myelin repair. These data raise fundamental questions about the proposed inhibitory role of …

KO of OLIG2 in OLIG2-expressing DIPG cells suggests that OLIG2 is not essentially required for maintaining proliferation in the tested DIPG cell lines, while OLIG2 deficiency or deletion leads …

Inactivation of Olig2 blocks stem cell activation and tumour output. Targeting this rare OLIG2-driven proliferative programme with a small molecule inhibitor, CT-179, dramatically attenuates …

Jul 7, 2016 · In this study, we demonstrate how the N-terminal phosphorylation of OLIG2 can regulate cell invasion through its transcriptional regulation of the TGFβ2 pathway. We show …

Mar 10, 2011 · We present evidence that OLIG2 controls the switch by reversible phosphorylation on Serine 147 (S147), a predicted protein kinase A (PKA) target; phosphorylation at this site is …

Mar 24, 2025 · The number of ALDH1L1/BrdU double-positive cells showed no significant change among control, Olig1 -KO, Olig2 -ECKO, and Olig1/2 -ECKO mice (Fig. S2A–S2C). …

Immunoblot analysis suggests that germline ablation (KO) or loss of amino-terminal phosphorylation (TPN) of Olig2 reduces the expression of Egfr in normal (WT) and …