Oct-4 (octamer-binding transcription factor 4), also known as POU5F1 (POU domain, class 5, transcription factor 1), is a protein that in humans is encoded by the POU5F1 gene. [5] Oct-4 is a homeodomain transcription factor of the POU family. It is critically involved in the self-renewal of undifferentiated embryonic stem cells. [6]

Maternal murine Oct-4 mRNA and protein (352 AA), deposited in the oocyte, are inherited by the zygote and are necessary for development until the 4-cell stage. Proteins are present at low levels at these early stages of murine embryogenesis.

This review mainly proposes the specific role of OCT4 in CSCs from the epigenetic modification of OCT4 and complexes, non-coding RNA and signaling pathways related to OCT4, which may provide multiple targets for the treatment of CSCs to achieve the purpose of extending patient life.

Jan 1, 2018 · OCT4 is a member of the class 5 POU (Pit-Oct-Unc) family of homeodomain transcription factors. It is so named because of its specific binding to the canonical octamer motif (with consensus sequence ATGCA/TAAT) at target gene promoter or enhancer regions.

In the past several years, genome-wide identification of Oct4 target genes and Oct4-centered protein interactomes has been reported, indicating that Oct4 exerts tight control over pluripotency regulator expression and protects embryonic stem cells in an undifferentiated state.

In this review, we summarize the structure and function of Oct4 and address issues related to Oct4 function in maintaining totipotency or pluripotency of embryonic stem cells.

5 days ago · OCT4 (Octamer-binding transcription factor 4, encoded by the POU5F1 gene) is a master transcription factor for maintaining the self-renewal and pluripotency of pluripotent stem cells, as well as a ...

OCT4 was discovered more than two decades ago as a transcription factor specific to early embryonic development. Early studies with OCT4 were descriptive and looked at determining the functional roles of OCT4 in the embryo as well as in pluripotent cell lines derived from embryos.

Mar 1, 2014 · OCT4 was discovered more than two decades ago as a transcription factor specific to early embryonic development. Early studies with OCT4 were descriptive and looked at determining the functional roles of OCT4 in the embryo …

Know comprehensive Oct4 protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.