OptoFGFR1, an optogenetic method to modulate the FGFR signaling pathway with light by utilizing PHR domain of cryptochrome2 and cytoplasmic region of FGFR1, enabled light …

Recently, it has been reported that conditional loss of FGFR1 signaling in oligodendrocyte progenitor cells (OPCs) and oligodendrocytes results in enhanced OPC differentiation and …

FGF receptor 1 (FGFR1) signaling inhibited differentiation of OPC into mature oligodendrocytes, as demonstrated by in vitro cell model and by conditional knockout of FGFR-1 in a chronic …

In recent EAE studies, we detected that oligodendrocyte-specific deletion of FGFRs results in a milder disease course, less cellular infiltrates, and reduced neurodegeneration in the spinal …

Feb 23, 2017 · FGFR1 is present on oligodendrocytes, astrocytes and neurons in humans 22 and rodents 56, where it has been shown to be expressed in both oligodendrocyte progenitor cells …

Here, we investigate the effects of members of the FGF1,-4, and -9 subfamilies on proliferation and differentiation of OL progenitors (OPCs), and on cell cycle re-entry and down-regulation of …

Oct 5, 2000 · Secreted FGF1 induced long-term activation of FGFR1 and ERK2, which was necessary to induce a constant and high level of Bcl-x production, and to induce cell survival in …

We found that Frs2 is required for specification of OPCs in the embryonic telencephalon downstream of Fgfr1. In contrast, Frs2 is largely dispensable for transducing Fgfr2-mediated …

Recent investigations of post-mortem tissue suggest that Fibroblast growth factor (FGF) signaling may regulate inflammation and myelination in MS. FGF2 expression seems to correlate …

Oct 27, 2022 · We proposed that it was possibly a combination of migration and proliferation that resulted in a reduction in the NG2+ OPC population at the oligodendrocyte genesis site when …