Mar 30, 2025 · NTN1 (Netrin 1) is a Protein Coding gene. Diseases associated with NTN1 include Mirror Movements 4 and Mirror Movements 1. Among its related pathways are Netrin-1 signaling and Nervous system development. An important paralog of this gene is NTN3. Netrins control guidance of CNS commissural axons and peripheral motor axons.

Netrin-1 is a protein that in humans is encoded by the NTN1 gene. [5][6] Netrin is included in a family of laminin-related secreted proteins. The function of this gene has not yet been defined; however, netrin is thought to be involved in axon guidance and cell migration during development.

Nov 27, 2024 · Netrin-1 elicits metastatic potential of non-small cell lung carcinoma cell by enhancing cell invasion, migration and vasculogenic mimicry via EMT induction. Zhang X, et al. Cancer Gene Ther, 2018 Feb. PMID 29234153. The neuroimmune guidance cue netrin-1: a new therapeutic target in cardiovascular disease.

Jun 28, 2024 · Netrin-1 (NTN1) was found up-regulated in nerve stump after peripheral nerve injury (PNI). Herein, we demonstrated that NTN1-high endothelial cells (NTN1+ECs) were the critical component of vascular niche, fostering angiogenesis, axon regeneration, and repair-related phenotypes.

Identification of putative regulatory single-nucleotide variants in NTN1 gene associated with NSCL/P. Netrin-1 promotes the vasculogenic capacity of human adipose-derived stem cells. Galphai1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.

Jan 25, 2025 · NTN1 exhibits substantial clinical utility as a prognostic marker and indicator of immune response across various tumor types. This comprehensive analysis provides insights into its potential implications in pan-cancer research.

Jan 27, 2021 · Our study suggests that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1 function. Decline of netrin-1 production during ageing leads to the gradual decrease of...

May 5, 2009 · Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively.

Sep 15, 2024 · Netrin-1 (NTN1) is involved in psychological alterations caused by central nerve system diseases. The primary objective of this research was to investigate whether a deficiency of neuron-derived NTN1 in the remote brain regions affects SCI outcomes.

Apr 18, 2023 · Netrin-1 (Ntn1) is a secreted ligand critical for vessel and neuronal guidance. Here, we demonstrate that Ntn1 is expressed by stromal progenitors in the developing kidney, and conditional deletion of Ntn1 from Foxd1+ stromal progenitors …