Jul 1, 2011 · NADPH oxidase-4 (Nox4) is an important modulator of redox signaling that is inducible at the level of transcriptional expression in multiple cell types. By contrast to other Nox enzymes, Nox4 is continuously active without requiring stimulation.

These data therefore demonstrate that Nox4 can activate the Nrf2-regulated pathway, and suggest a potential role for Nox4 in the regulation of GSH redox in cardiomyocytes.

Apr 1, 2015 · ROS production is increased in Nrf2-KO and Keap1-KD neurons when compared to WT. NOX2/NOX4 mRNA in Nrf2-KO and Keap1-KD paralleled these changes. Nuclear factor (erythroid-derived 2) factor 2 (Nrf2) is a crucial transcription …

Jul 14, 2022 · Moreover, we found that Nox4 promoted survival of CAFs via activation of Nrf2, a master regulator of oxidative stress response. We have further shown Birc5 is involved as a downstream modulator of Nrf2-mediated pro-survival phenotype.

These data define a novel endogenous link between Nox4 and Nrf2 and suggest that the Nox4/Nrf2 axis may serve as a unique redox rheostat to respond to oxidative stress.

Exercise induces NOX4 expression in the heart, which activates Nrf2 and increases endurance capacity. Mice transiently depleted of SOD2 or overexpressing skeletal muscle-specific UCP1 exhibit Nrf2-mediated antioxidant gene expression and …

Jul 14, 2022 · We found that deletion of stroma Nox4 and pharmaceutically targeting its activity with GKT137831 significantly inhibited orthotopic tumor growth and metastasis of implanted E0771 and 4T1 murine mammary carcinoma cell lines in mice.

Mar 15, 2017 · In the present study, we found that NOX4 overexpression could significantly enhance Nrf2 stability and activity, and inhibition of Nrf2 activity resulted in an obvious apoptotic death of NOX4-overexpressed A549 cells.

Apr 9, 2014 · Our studies suggest that restoration of Nox4-Nrf2 redox balance in myofibroblasts may be a therapeutic strategy in age-associated fibrotic disorders, potentially able to resolve persistent fibrosis or even reverse its progression.

Jul 14, 2022 · Nox4 overexpressing CAFs depend on the Nrf2 (nuclear factor-erythroid factor 2-related factor 2) pathway for survival. We then determined the dependency of Nox4-overexpressing CAFs on the Nrf2-mediated adaptive stress response pathway for survival.