Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. [5] NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury ...

Mar 30, 2025 · NFE2L2 (NFE2 Like BZIP Transcription Factor 2) is a Protein Coding gene. Diseases associated with NFE2L2 include Immunodeficiency, Developmental Delay, And Hypohomocysteinemia and Squamous Cell Carcinoma, Head And Neck. Among its related pathways are Nuclear events mediated by NFE2L2 and Infectious disease.

Recent studies have identified new NRF2 target genes and revealed several new functions of NRF2 that go beyond its redox-regulating capacities, including regulation of inflammation, autophagy, metabolism, proteostasis, and unfolded protein response (UPR), particularly in the context of carcinogenesis.

Nrf2 plays a role in regulating the anti-inflammatory response through redox control and activation of ARE-mediated anti-inflammatory genes, including the expression of the antioxidant genes NQO1, HO-1, and PRX1, all of which exhibit anti-inflammatory effects [191,192,193,194].

Jul 6, 2020 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.

Decreased cortical Nrf2 gene expression in autism and its relationship to thiol and cobalamin status. Nrf2 deficiency decreases NADPH from impaired IDH shuttle and pentose phosphate pathway in retinal pigmented epithelial cells to magnify oxidative stress …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes. Understanding the regulation of Nrf2 activity and downstream pathways has major implications for human health.

Feb 19, 2025 · The nrf2 gene promoter mutation T336C intensifies organ inflammation and damage of mice with alcoholic liver disease and Vibrio vulnificus sepsis. This study confirms the central role of Nrf2 in the induction of multiple defense proteins as well as its control in the constitutive expression of certain proteins.

Nov 23, 2020 · Nrf2 and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH- associated protein 1 (Keap1), play a central role in the maintenance of intracellular redox homeostasis and regulation of inflammation.

Apr 7, 2025 · Gene set enrichment analysis indicated that Nrf2-bound genes associated with neuroprotective pathways, such as axon development and neuron development (with significant overlap with genes involved in synaptic plasticity), as well as autophagy (proteolysis involved in protein catabolic process) genes that were significantly downregulated in AD ...