Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. [5] NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury ...

Jul 6, 2020 · Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification.

Nuclear factor erythroid 2-related factor 2 (Nrf2) is the transcriptional master regulator of cellular responses against oxidative stress.

Stabilized following oxidative stress, Nrf2 induces the expression of antioxidants as well as cytoprotective genes, which provoke an anti-inflammatory expression profile, and is crucial for the initiation of healing.

Nov 23, 2020 · Nrf2 and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH- associated protein 1 (Keap1), play a central role in the maintenance of intracellular redox homeostasis and regulation of inflammation.

Mar 4, 2025 · NRF2 has emerged as a master regulator of cellular homeostasis, orchestrating redox balance, metabolic stability, proteostasis and intracellular iron dynamics — collectively shaping...

Sep 20, 2024 · The NRF2 pathway is intricately regulated by a host of molecular players that act to modulate its activity in response to cellular signals. Among these, the role of glycogen synthase kinase 3 beta (GSK-3β) is particularly noteworthy.

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the cellular defense against toxic and oxidative insults through the expression of genes involved in oxidative stress response and drug detoxification. NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges.

NRF2 activators initiate a protective cellular response by engaging with the NRF2 pathway, thereby enhancing the body's defense against oxidative stress and inflammation. When you dive deeper into the activation mechanisms, you'll find that NRF2 activators work by detaching NRF2 from its inhibitor, KEAP1.

In this review, we describe the pharmacological activators of NRF2 that are in several stages of pharmacological development for the treatment of several chronic diseases. The most developed compounds activate NRF2 by preventing its degradation by KEAP1-dependent mechanisms.