NOX4-mediated ROS production can be induced by hypoxia [89] and by stimulation with lipopolysaccharide [90], insulin [91], and angiotensin [92]. NOX4 is localized in mitochondria [93], endoplasmic reticulum (ER) [94], focal adhesion [95], nuclei [96], …

Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively active.

Aug 15, 2011 · Here we report that H-RasV12 positively regulates the NADPH oxidase system NOX4-p22 phox that produces H 2 O 2. Knocking down the NADPH oxidase with small interference RNA decreases...

Oct 26, 2023 · In cancers, dysregulation of NOX enzymes affects ROS production, leading to redox unbalance and tumor progression. Consequently, NOXs are a drug target for cancer therapeutics, although current...

NADPH Oxidase 4 (NOX4), a member of the NOX family, has emerged as a significant source of reactive oxygen species, playing an important role in tumor cell proliferation, apoptosis, and other physiological processes.

Increased generation of reactive oxygen species (ROS) has been implicated in the pathogenesis of a variety of diseases such as cardiovascular diseases and cancer. NADPH oxidase (Nox), a multicomponent enzyme, has been identified as one of the key sources of ROS.

Jun 23, 2023 · Nox4 forms a heterodimeric complex with the membrane protein p22 phox that stabilizes it and enhances its reactive oxygen species (ROS)-generating activity [5, 6, 7], but unlike Nox1 and Nox2, it does not require traditional cytosolic subunits or Rac for activity [6].

Hypoxia conditions activate NOX4 and NOX2, inducing the production of ROS and thereby enhancing VEGFR2 signaling and angiogenesis in ECs. Nox4-derived H 2 O 2 also activates NOX2 to promote superoxide production.

Jun 6, 2008 · The principal finding of this study is that endothelial Nox4, an endogenous source of ROS in HAECs, is localized to the ER and appears involved in the regulation of another ER-residing protein, PTP1B, in a spatially dependent manner.

Mar 27, 2012 · Endogenous Nox4 protects the vasculature during ischemic or inflammatory stress. Different from Nox1 and Nox2, this particular NADPH oxidase therefore may have a protective vascular function. Reactive oxygen species (ROS) exert a range of different effects in the vascular system.