NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene, and is a member of the NOX family of NADPH oxidases. [5] Oxygen sensing is essential for homeostasis in all …

Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively …

Aug 31, 2010 · These results suggest that Nox4 in cardiac myocytes is a major source of mitochondrial oxidative stress, thereby mediating mitochondrial and cardiac dysfunction during …

This article explores the experimental studies related to the gene, structure, physiological function and pathological significance of Nox4. As Nox4 might serve as a potential target for the …

Jun 23, 2023 · Nox4, originally termed Renox, was discovered in 2000. Since that time, our understanding of its structure and function has expanded enormously. Nox4 is ubiquitously …

A central role for Nox4 in the regulation of vascular cell function and cardiovascular disease. FORM: Nox4 spans the membrane six times and produces hydrogen peroxide constitutively …

Mar 30, 2025 · NOX4 (NADPH Oxidase 4) is a Protein Coding gene. Diseases associated with NOX4 include Ureteral Obstruction and Asbestosis. Among its related pathways are FLT3 …

Aug 12, 2014 · Critically, Nox4 has an unusually high Km for oxygen (∼18%), similar to the values of known oxygen-sensing enzymes, compared with a Km of 2-3% for Nox2, the phagocyte …

NOX4, which is highly expressed in the kidney, osteoclasts, fibroblasts and endothelial cells, shares a common catalytic core with NOX1 to 3, but shares only 39% identity with NOX2. Like …

NOX4 encodes an NADPH oxidase, which produces reactive oxygen species (such as superoxide) by transferring electrons from NADPH to molecular oxygen. You might find these …