NADPH oxidase 1 is an enzyme that in humans is encoded by the NOX1 gene. [5] NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Two transcript variants encoding different isoforms have been found for this gene. [6]

Jun 1, 2021 · NOX from phagocytes catalyzes, via one-electron trans-membrane transfer to molecular oxygen, the production of the superoxide anion. Over the years, six human homologs of the catalytic subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2.

Mar 30, 2025 · NOX1 (NADPH Oxidase 1) is a Protein Coding gene. Diseases associated with NOX1 include Visceral Myopathy 1 and Chronic Granulomatous Disease. Among its related pathways are Signaling by Rho GTPases and Alzheimer's disease and miRNA effects. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity and …

Human isoforms of the catalytic component of the complex include NOX1, NOX2, NOX3, NOX4, NOX5, DUOX1, and DUOX2. [1] NADPH oxidase catalyzes the production of a superoxide free radical by transferring one electron to oxygen from NADPH. [2]

May 18, 2022 · NOX is a multisubunit protein complex that generates superoxide anions or H 2 O 2 by transferring electrons from cytosolic NADPH to molecular oxygen.

NOX1 and NOX3 constitute the closest isoforms to phagocytic NADPH oxidase , sharing 60% sequence identity with NOX2. NOX1 constitutes the predominant isoform in the colon, prostate, uterus and vascular cells [46,76,181]. NOX3 is typically expressed in the inner ear.

NOX1 deficiency plus TNFα stimulation contribute to colitis through dysregulation of the stem cell niche and altered cell differentiation, enhancing basal lymphoplasmacytosis. Our findings prioritise ROS modulation for future therapies.

NOX1 is located at chromosome Xq22 and codes for a protein of predicted length of 565 amino acids that shares 56% identity with gp91 phox. Recent work suggests it may be regulated by its own versions of p47 phox and p67 phox , NOXO1 and NOXA [114] .

Nox1 is activated in vascular cells in response to several different agonists, with its activity regulated at the transcriptional level as well as by NADPH oxidase complex formation, protein stabilization and post-translational modification.

Jan 4, 2025 · Role of NOX1 and NOX5 in protein kinase C/reactive oxygen species-mediated MMP-9 activation and invasion in MCF-7 breast cancer cells. NOX1 triggers ferroptosis and ferritinophagy, contributes to Parkinson's disease.