Abstract BACKGROUND. Severe open tibia fractures are challenging to treat with a lack of published clear management strategies. Our aim was to provide an overview of the largest single-center experience in the literature, with minimum 1-year follow-up, of adult type 3 open tibial shaft fractures at Cambridge University Hospitals (a United Kingdom major trauma center).

Using national registry data, we studied the effect of delayed treatment on survival in breast cancer patients. We found that extended treatment delay (>90 days postdiagnosis) resulted in worse overall survival in patients with invasive nonmetastatic and metastatic breast cancer but not in patients with noninvasive breast cancer.

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The current trend for determining the effectiveness of new treatment or services provided for diabetes mellitus (DM) patients is based on assessing the improvement in both glycemic control and the patient quality of life. Many scales have been ...

One hundred fifty-four males attending an outpatient diabetes clinic were interviewed to determine the incidence of alcohol use among them and to identify mechanisms by which alcohol use adversely affects the control of diabetes. Specifically, we determined how diabetic patients' use of …

The impact of timely treatment on breast cancer-specific survival may differ by tumor stage. We aim to study the impact of delayed first treatment on overall survival across different tumor stages. In addition, we studied the impact of delayed adjuvant treatments on …

BK virus nephropathy (BKVN) occurs in up to 10% of renal transplant recipients and can result in graft loss. The reactivation of BK virus in renal transplant recipients is largely asymptomatic, and routine surveillance especially in the first 12-24 months after transplant is necessary for early reco …

Objective: We aimed to validate the Malay version of Diabetes Quality of Life (DQOL) questionnaire for Malaysian adult population with type 2 diabetes mellitus (DM). Methods: This is a cross-sectional study to validate Malay version of DQOL among the adult diabetic patients. DQOL questionnaire has 46 items consist of three domains, namely Satisfaction Domain, Impact Domain and Worry Domain.

For more than a decade, it has been known that NF-κB is constitutively activated in a majority of acute myeloid leukemia (AML) patients which contributes to the resistance to apoptosis. Inhibition of NF-κB has been shown to induce apoptosis in AML …

1. Introduction. Breast cancer is the most common non-cutaneous cancer among women in the United States, comprising 14.8% of all new cancer cases and 7.2% of all cancer deaths annually. 1 Although breast cancer is considered a disease primarily impacting older women, 5–10% of new diagnoses occur in younger women aged <40 years. 1 Among young women, breast cancer often presents with more ...