Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a family of transcription factor protein complexes that controls transcription of DNA, cytokine production and cell survival.

Jul 14, 2017 · NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells. Innate immune cells, including macrophages, dendritic cells...

Dec 8, 2009 · After gaining access to the nucleus, NF-κB must be actively regulated to execute its fundamental function as a transcription factor. Recent studies have highlighted the importance of nuclear...

In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-κB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway.

Nuclear factor kappa B (NFκB) is a family of dimeric transcription factors central to coordinating inflammatory responses; innate and adaptive immunity; and cellular differentiation, proliferation, and survival in almost all multicellular organisms. 1 – 4 The NFκB system is tightly regulated, and misregulation of NFκB has been implicated in a wi...

It plays important roles in the control of immune function, inflammation, stress response, differentiation, apoptosis, and cell survival. Moreover, NF-kappaB is critically involved in the processes of development and progression of cancers.

In this article, we describe how genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway.

Nuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are several pathways leading to NF-kappa B-activation.

NF-κB is a central mediator of pro-inflammatory gene induction and functions in both innate and adaptive immune cells. Innate immune cells, including macrophages, dendritic cells and neutrophils, are important players of innate immunity and inflammation.

NFkappaB was identified 20 years ago (Sen, R., & Baltimore, D. (1986) Cell, 46, 705-716) as a nuclear factor that binds the kappa light chain enhancer in B-cells (and hence, the name NFkappaB) and was shown to play roles in innate and adaptive immune responses.