Feb 21, 2025 · We demonstrate that SOCE promotes nuclear factor of activated T cells (NFAT) binding to conserved noncoding sequence (CNS)-12 in the TBX21 enhancer and enables NFAT to synergize with STAT1 to...

In this study, we define a mechanism by which the calcineurin/NFAT and Jak/STAT pathways regulate CryAB gene expression in response to a hypertrophic agonist endothelin-1 (En-1), in hypertrophic hearts of mice with pressure overload (TAC) and in heart-targeted calcineurin over-expressing mice (MHC-CnA).

Jul 14, 2023 · In this study, we identified NFAT1 as an independent prognostic factor for glioma patients by conducting differential expression analysis of NFAT1 in pan-cancer and investigating its role in...

Jun 1, 2005 · Experimental evidence indicates that, during T-cell development, calcium–calcineurin–NFAT signalling is a key regulator of positive selection. NFAT2 and NFAT4 might also control thymocyte...

May 15, 2014 · Each of the novel NFAT/STAT elements was found to interact with the Pdcd1 promoter region in CD8 T cells, demonstrating that they are likely to contribute directly to Pdcd1 transcription. Together, these results introduce new pathways that integrate multiple mechanisms to stimulate and regulate PD-1 in response to different environmental cues.

Jun 16, 2009 · Recent studies implicate calcineurin/NFAT and Jak/STAT signalling in both beneficial and detrimental responses in the heart [12, 13]. In this report, we demonstrated a link between these signalling pathways and expression of …

Jan 1, 1999 · Herein we demonstrate that the inducible nuclear import of NF-kappa B, AP-1, NFAT, and STAT1 in Jurkat T lymphocytes is significantly inhibited by a cell-permeable peptide carrying the NLS of the...

Dec 1, 1998 · Herein we demonstrate that the inducible nuclear import of NF-κB, AP-1, NFAT, and STAT1 in Jurkat T lymphocytes is significantly inhibited by a cell-permeable peptide carrying the NLS of the NF-κB p50 subunit.

Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of cardiac, skeletal muscle, and nervous systems.

Dec 1, 1998 · Herein we demonstrate that the inducible nuclear import of NF-kappa B, AP-1, NFAT, and STAT1 in Jurkat T lymphocytes is significantly inhibited by a cell-permeable peptide carrying the NLS of the NF-kappa B p50 subunit.