Feb 17, 2015 · During persistent antigen stimulation, CD8 (+) T cells show a gradual decrease in effector function, referred to as exhaustion, which impairs responses in the setting of tumors …

Sep 11, 2017 · NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection.

NFAT proteins induce a transcriptional program of CD8 + T cell exhaustion. An engineered NFAT that cannot cooperate with AP-1 strongly induces exhaustion. The engineered NFAT1 blunts …

Dec 12, 2024 · To examine factors downstream of TCR signaling, we focused on nuclear factor of activated T cells (NFAT), a transcription factor that orchestrates CD8 + T cell activation and …

Here we found that NFAT5, an NFAT family transcription factor that lacks an AP-1 docking site, was highly expressed in exhausted CD8 + T cells in the context of chronic infections and …

Jun 30, 2022 · Dapl1 controls activation of NFATc2, a transcription factor required for the effector function of CD8 + T cells. Although NFATc2 mediates induction of the immune checkpoint …

Our findings demonstrate that GSK3 inhibits the nuclear translocation of NFAT in activated CD8 + T cells, thereby restraining the NFAT-TOX-mediated T-cell exhaustion program during acute …

NFAT deficiency results in dysregulated expression of Tbet and Eomes, two essential transcription factors that can determine CD8 + T cell fate commitment. While single NFAT …

Feb 17, 2015 · We defined the genomic regions occupied by endog-enous and engineered NFAT1 in primary CD8+ T cells and showed that genes directly induced by the engi-neered …

5 days ago · Moreover, anergic CD8 + T cells have been reported to exhibit defects in intracellular Ca 2+ signalling coupled with dysfunctional NFAT and AP-1 signalling in transgenic T cell …