In summary, both c-Fos and pERK can be used as markers for neuronal activation following noxious stimulation and tissue injury, but pERK is much more dynamic and appears to be a better marker for central sensitization.

The activation of c-fos and c-Fos in the brain is induced by various stimuli and used as a tool to study cell activation and external cellular signals with phenotypic changes in nerve cells. The level and timing of gene expression, as well as its product, varies according to the stimulus and the area studied, as well as the mechanisms of action.

Sequential changes in brainstem and spinal cord neurons after traumatic injury to peripheral nerves are related to neuropathic pain symptoms. This study was conducted to elucidate the influence of nerve insult on stimulus-induced c-Fos expression and ERK phosphorylation by brainstem neurons.

For the transcription of c-fos, neural activity should be strong enough to activate mitogen-activated protein kinase (MAPK) signaling pathway which shows low calcium sensitivity. Upon translation, the auto-inhibition by Fos protein regulates basal Fos expression.

Mar 4, 2002 · Our results suggest that c-fos is a genetic regulator for cellular mechanisms mediating neuronal excitability and survival.

A dramatic and specific induction of c-fos was observed in identifiable neuronal populations in vivo after administration of the convulsant Metrazole. This effect was time- and dose-dependent and was abolished by prior treatment with the anticonvulsant drugs diazepam or pentobarbital.

Expression of c-Fos has been used to determine the neuronal circuits underlying the neuroendocrine, autonomical, and behavioral responses induced by stress. c-Fos mapping indicates that acute stress challenges activate the HPA axis, specifically the CRF-containing parvocellular neurons of the hypothalamus.

Apr 1, 1990 · The high resolution of fos immunohistochemistry and the widespread occurrence of fos activation during the electrical excitation of neurons may prove to be valuable for mapping functional excitation pathways in the central nervous system (Morgan et al., 1987).

Differential effects of lingual or IAN injury on stimulus-induced c-Fos expression and ERK phosphorylation by Vo and Vc neurons may be involved in the complex nature of symptoms of trigeminal neuralgia.

Oct 24, 2007 · Summary data for the effects of acute (left) and chronic (right) vagus nerve stimulation (VNS) on Fos and ΔFosB staining in the NTS.