NOX2 is an isoform from NADPH oxidase expressed in platelets and an important regulator of platelet activation-associated thrombosis. The present article aims to highlight the relative contribution of NOX2 as a key target of different platelet …

Oct 11, 2019 · Here, we combined exercise in humans and mice with fluorescent dyes, genetically-encoded biosensors, and NADPH oxidase 2 (NOX2) loss-of-function models to demonstrate that NOX2 is the main...

NADPH oxidase 2 (Nox2), also known as cytochrome b(558) subunit beta or Cytochrome b-245 heavy chain, is a protein that in humans is encoded by the NOX2 gene (also called CYBB gene). [5] The protein is a superoxide generating enzyme which forms reactive oxygen species (ROS).

Although NOX2-mediated ROS generation promotes glucose oxidation, a metabolic-dependent feedback loop allows glycolysis to increase the expression of NOX2 and p47 phox to improve the ability of macrophages to produce ROS.

Together with the phagocyte NADPH oxidase itself (NOX2/gp91 (phox)), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS).

Oct 15, 2011 · NOX2-derived ROS have been shown to suppress antigen-dependent T-cell reactivity and remarkably to reduce the severity of experimental arthritis in both rats and mice. In this review, we discuss the role of ROS and the NOX2 complex as suppressors of autoimmunity, inflammation, and arthritis.

In this review, we summarize recent progress regarding immune regulation by NOX2-derived ROS and the consequences of its deregulation on the development of immune disorders. Keywords: Immune regulation, Autoimmunity, NOX2, Antigen presentation. 1. Introduction. ROS is an umbrella term for several chemical derivatives of oxygen (O 2).

Oct 14, 2022 · NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces superoxide (O 2•−), a key reactive oxygen species (ROS) that is essential in innate and adaptive immunity.

NOX2, activated by TNFα, thrombin or NF-κB-induced ROS, promotes migration and angiogenesis via the Akt and cSrc pathways. NOX2-mediated regulation of angiogenesis also occurs via cadherin, p38 activation or regulation of ERK1/2 activation mediated by NOX4-derived H …

Aug 28, 2010 · The NOX2 NADPH oxidase in particular has been assigned multiple roles, functioning as a source of antimicrobial ROS, an activator of many signaling pathways, a participant in chemotaxis, an immune modulator, and a critical player in the initiation of antigen cross-presentation.