While NGS is superior at variant calling to TGS thanks to its lower error rates, the longer reads nature of the TGS permits haplotype-phasing that is superior for variant discovery on the …

Distinct from NGS platforms that generate relatively short reads (up to ~600 nt), TGS is characterized by improved sequencing chemistry, leading to the production of long reads, with …

Currently, the NGS is still our first choice of diagnosing the genetic diseases in clinical settings and the TGS can play a complementary role as a result of its limitations. However, with the …

Chen et al. give a brief description of NGS in cancer research, outline the limitations of NGS and then present a comprehensive review of key applications of third-generation sequencing (TGS)...

Nov 1, 2022 · NGS and TGS approaches promote the understanding of interactions and synergies of microbial communities present in the human body, and such understanding is …

May 20, 2021 · Although many variant callers are available, no single caller can call both types of variants on NGS or TGS data with high sensitivity and specificity. In this study, we …

Sep 1, 2023 · New genomic technologies, such as third generation sequencing (TGS), have enabled for high-throughput, rapid, and cost-effective data generation of non-model …

Aug 29, 2023 · NGS technologies typically have higher throughput and overall accuracy across non-complex regions than TGS. This means that an NGS platform will deliver deeper …

Jan 19, 2023 · While NGS is superior at variant calling to TGS thanks to its lower error rates, the longer reads nature of the TGS permits haplotype-phasing that is superior for variant discovery …

Dec 26, 2021 · This review highlights the advantageous features of the newly introduced TGS technologies, discusses their limitations and provides an in-depth comparison regarding their …