Jul 24, 2019 · HCT116 cells that lack YAP were no longer sensitized to ferroptosis after NF2 RNAi (Fig. 3d and Extended Data Fig. 8l), demonstrating that NF2 suppresses ferroptosis by …

Our results demonstrate the role of intercellular interactions and intracellular NF2-YAP signalling in dictating ferroptotic death, and also suggest that malignant mutations in NF2-YAP signalling …

Here, by employing NF2 deficient RCC and schwannoma cells engineered to inducibly express shRNAs targeting YAP and TAZ, we have systematically examined the effects and …

Using liver-specific conditional knockout mice, we demonstrate that the Merlin/NF2 tumor suppressor and the YAP oncoprotein function antagonistically to regulate liver development. …

Our data revealed differential roles of NF2 and YAP signaling in the pathogenesis of MPM, as indicated by different molecular signatures, drug sensitivity and immune profiles, indicating …

Mar 29, 2021 · Furthermore, we observe that NF2 physically interacts with a considerable number of proteins that are not involved in the canonical Hippo-YAP pathway, providing a possible …

May 6, 2019 · Using an inducible orthotopic kidney tumor model, we demonstrate that YAP/TAZ silencing is sufficient to induce regression of pre-established NF2-deficient tumors. …

Jun 11, 2022 · NF2 or Hippo pathway inactivation is found in 50% of malignant mesothelioma patients. Experimental disruption of the NF2–Hippo axis in mesothelioma cell lines activated …

Apr 14, 2022 · Furthermore, the NF2–YAP signaling axis modulated the expression of ferroptosis suppressor protein 1 (FSP1) and CD24 in CD24 high cells, with subsequent ferroptotic …

Oct 5, 2022 · Mechanistically, BNC1 deficiency triggers oocyte ferroptosis via the NF2-YAP pathway. We demonstrated that pharmacologic inhibition of YAP signaling or ferroptosis …