Jul 16, 2019 · Our study provides new insight into the mechanisms of merlin-dependent Ras regulation and may have additional implications for merlin-dependent regulation of other small …

Jun 15, 2024 · In this review, we consolidate the current knowledge on NF2 and examine the potential connection between cancer metabolism and tumor immunity in merlin-deficient …

While NF2 has not been shown to directly bind Ras, it significantly hinders its downstream signaling 59 by preventing Ras upregulation of AP-1 activity and cyclin D1 expression 78. NF2 …

The UC Davis NF/Ras Pathway Clinic provides comprehensive health care support and management for children and adults throughout their life span who have or are at risk for …

We show that NF2/merlin inactivation augments mutant RAS signaling by promoting YAP/TEAD-driven transcription of oncogenic and wild-type RAS, resulting in greater MAPK output and …

Our study provides new insight into the mechanisms of merlin-dependent Ras regulation and may have additional implications for merlin-dependent regulation of other small GTPases. …

Apr 19, 2000 · Mutations in the neurofibromatosis type II (NF2) tumor suppressor predispose humans and mice to tumor development. The study of Nf2+/− mice has demonstrated an …

Sep 23, 1994 · Furthermore, NF2-N also suppresses the Ras-induced malignant phenotype, although it appears to be less effective than the full-length NF2. These observations indicate …

To investigate the contribution of Ras hyperactivity to Nf2 loss-induced focus formation, we constructed a Ras-inhibitory protein (Ras-i) consisting of EGFP, the Ras-binding domain …

Here we demonstrate that merlin can directly interact with both Ras and p120RasGAP (also named RasGAP). While merlin does not increase the catalytic activity of RasGAP, the …