Apr 1, 2020 · An NF2 mutant deficient in lipid binding is unable to activate the Hippo pathway in response to osmotic stress, as measured by LATS and YAP phosphorylation. Our findings …

Jul 4, 2022 · To investigate how MCB and VT01454 activate the Hippo kinase cascade, we examined the expression of key Hippo pathway components, NF2 membrane localization and …

In this study, Hong et al. provide new insights into how NF2 mediates upstream signals to regulate the Hippo pathway. They show that NF2's lipid-binding ability is critical for its function in …

Jun 15, 2024 · Yang, H. et al. NF2 and canonical Hippo-YAP pathway define distinct tumor subsets characterized by different immune deficiency and treatment implications in human …

Mar 29, 2021 · Furthermore, we observe that NF2 physically interacts with a considerable number of proteins that are not involved in the canonical Hippo-YAP pathway, providing a possible …

Aug 19, 2016 · NF2 promotes I/R injury through the activation of Mst1 and inhibition of Yap, thereby regulating Hippo signaling in the adult heart. NF2 is activated by oxidative stress in …

These findings indicate that NF2 facilitates activation of the core Hippo pathway kinase Mst1, and negatively regulates the transcription co-factor Yap, to influence cardiomyocyte apoptosis and …

Sep 12, 2013 · Understanding how the multiple regulatory inputs into Wts/Lats are coordinated will shed light on the physiological regulation of Hippo signaling in normal development and …

Feb 27, 2020 · NF2 is a well-established tumor suppressor, and loss of NF2 severely compromises Hippo pathway activity. However, the precise mechanism of how NF2 mediates …

NF2’s lipid-binding ability is critical for its function in activating the Hippo pathway in response to osmotic stress. Mechanistically, osmotic stress induces PI(4,5)P2 plasma membrane …