Feb 3, 2011 · We generated a transgenic mouse line that expresses the Cre recombinase under the control of the Ncr1 (p46) promoter. Cre-mediated recombination was tightly restricted to natural killer (NK) cells, as revealed by crossing Ncr1 …

If you need help with your order, contact Customer Support. For in-depth product & services help, ask our Technical Information Scientists. 022739 B6;129-<i>Ncr1^tm1Oman</i>/J <em>Ncr1^gfp</em> mice are useful when tracking …

Generation of Ncr1tm1.1 (icre)Viv. Show the 1 phenotype image (s) involving this allele. Mutation details: An IRES-icre-Frt-neo-Frt cassette was inserted at the 3' end of the Ncr1 (Nkp46) gene by homologous recombination. The resulting mice were crossed to an Flp expressing strain to excise the neo resistance cassette. (J:180265)

Sep 17, 2018 · Reduced expression of CD3ζ in Klrk1−/− mice was associated with enhanced signal transduction through NCR1, and CD3ζ deficiency resulted in hyper-responsiveness to stimulation via NCR1. Thus, an...

Feb 1, 2011 · We generated a transgenic mouse line that expresses the Cre recombinase under the control of the Ncr1 (p46) promoter. Cre-mediated recombination was tightly restricted to natural killer (NK)...

Oct 12, 2017 · Natural Killer (NK) cells employ activating receptors like the Natural Cytotoxicity Receptors (NCRs: NKp30, NKp44 and NKp46), of which only NKp46 has a mouse orthologue (Ncr1), to eliminate...

Detection of tdTomato (red) in various tissues of Ncr1 Cre/+;Rosa26 tdTomato/+ mice. (For more detailed information please contact our technical advisor.)

This mouse strain is a novel Natural Killer cell specific inducible cre that is useful for studying the development, maturation, and function of NK cells. It has a tamoxifen inducible Ncr1-ERT2iCre mouse allele that is used for floxing gene(s) of interest out of NK cells.

Feb 3, 2011 · We generated a transgenic mouse line that expresses the Cre recombinase under the control of the Ncr1 (p46) promoter. Cre-mediated recombination was tightly restricted to natural killer (NK) cells, as revealed by crossing Ncr1 …

Nov 15, 2013 · We find that MHC-I expression by NK cells (cis) and by T cells (trans), and MHC-I recognition in cis and in trans, are both needed for NK cell licensing.