MyoD, also known as myoblast determination protein 1, [5] is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, [6] belongs to a family of proteins known as …

The discovery of the skeletal muscle-specific transcription factor MyoD represents a milestone in the field of transcriptional regulation during differentiation and cell-fate reprogramming. MyoD was the first tissue-specific factor found capable of ...

Jan 11, 2022 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the establishment of...

Discovery of the myogenic regulatory factor family of transcription factors MYF5, MYOD, Myogenin and MRF4 was a seminal step in understanding specification of the skeletal muscle lineage and control of myogenic differentiation during development.

MyoD differentially promotes activated and repressed chromatin structures at myogenic genes early after the onset of skeletal muscle differentiation in the developing mouse embryo. Keywords: myogenesis, somite, gene expression, gene regulation, Pbx, histone deacetylase.

MyoD and Myf5 are basic helix-loop-helix transcription factors that play key but redundant roles in specifying myogenic progenitors during embryogenesis. However, there are functional differences between the two transcription factors that impact ...

Apr 20, 2010 · MyoD is a classic master regulator that commits those somite cells in which it is expressed to a myoblast fate and also later activates skeletal muscle genes during the differentiation of these cells.

MyoD is a master transcription regulator belonging to the basic-helix-loop-helix protein family, crucial for the terminal differentiation of skeletal muscle and involved in myofibroblast presence during tissue repair/fibrosis. You might find these chapters and articles relevant to this topic.

Oct 1, 2015 · MyoD overexpression inhibited Twist-1 through miR-206 induction, which was followed by an increase in muscle cell differentiation. These results reveal a previously unidentified mechanism of myogenesis that might also play an important role in muscle disease.

Dec 7, 2019 · MyoD works in the context of both bHLH E protein dimerization partners and the homeobox protein Pbx to bind to relevant targets in both proliferating myoblasts and in differentiated myotubes.