CDK4 and CDK6 interact with c-Myb in human cells. The c-Myb protein has been linked to the regulation of proliferation 7, 8 and can interact with cyclin D1. 37 We used coimmunoprecipitation assays to test whether c-Myb also formed stable complexes with cyclin-dependent kinases (CDKs) in animal cells. As a first approach, we used a ...

Inhibition of CDK2 and CDK4/6 functions has been found to suppress the growth of triple negative breast cancer cells (TNBC), which manifests itself in loss of expression of the RB protein, or high expression of cyclin E, which are thought to confer resistance to treatment with CDK4/6 inhibitors.

This review discusses the role that CDK4 plays in cell cycle control, normal development and tumorigenesis as well as the current status and utility of approved small molecule CDK4/6 inhibitors that are currently being used as cancer therapeutics. Keywords: CDK4/6, cancer, cell cycle, targeted therapy, checkpoint inhibitor.

Feb 2, 2018 · We show here that: i) the growth of Ph+ ALL cell lines and primary cells is highly dependent on MYB-mediated transcriptional upregulation of CDK6, cyclin D3, and BCL2 and ii) restoring their expression in MYB-silenced Ph+ ALL cells …

Feb 22, 2011 · For example, c-Myb interacts with Cyclin D1 and with cyclin-dependent kinases CDK4 and CDK6 . In addition, c-Myb has been shown to regulate the CCNB1 gene, which encodes the cell cycle regulator Cyclin B1 , and has been implicated in the regulation of the CCNE1 gene, which encodes Cyclin E1 .

This study showed that the expression of miR‑34a negatively correlates with the expression of CDK4 and MYB in pediatric patients with acute leukemia. miRNA‑34a downregulates the expression of the CDK4, MYB and SIRT1 genes in vitro; it may thus represent a novel therapeutic target for acute leukemia.

CDK4 overexpression is a predictive biomarker for resistance to conventional chemotherapy in patients with osteosarcoma. Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK. CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism.

Jul 11, 2022 · CDK-dependent phosphorylation of B-MYB and FOXM1 during S/G2 may facilitate activation of MMB:FOXM1 (Figure 4, G2/mitosis). CCNE1 overexpression promotes B-MYB phosphorylation and G2/M gene expression , highlighting the link between CDK phosphorylation and MBM:FOXM1

Dec 8, 2017 · By contrast, expression of CDK4 was not regulated by MYB and was not required for the proliferation of Ph+ ALL cells, a finding likely explained by the fact that by immunofluorescence, CDK6 is readily detected in the nucleus of Ph+ ALL cells, whereas CDK4 appears exclusively in the cytoplasm.

The pathway starts with inappropriate activation of cyclin dependent kinase 4 (Cdk4) in neurons which leads to hyper-phosphorylation of the pRb family member p130. This in turn results in dissociation of p130 and its associated chromatin modifiers Suv39H1 and HDAC1 from the transcription factor E2F4.